HBV-specific T cell dysfunction is believed to play a central role in the pathogenesis
of chronic HBV persistence [
1
,
2
]. HBV-specific T cells are more dysfunctional within the liver than in the periphery
[
[3]
] as a result of the inhibitory effect of different mechanisms. They are likely to
be active simultaneously within the inflamed liver together contributing to T cell
functional impairment [
4
,
5
]. Some of them have been directly characterized in HBV infection, while others are
assumed to be relevant because of their general importance within the liver.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 08, 2017
Accepted:
October 3,
2016
Received in revised form:
October 3,
2016
Received:
August 23,
2016
Identification
Copyright
© 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
