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Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

  • Marcel Klingenberg
    Affiliations
    Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany

    Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany
    Search for articles by this author
  • Akiko Matsuda
    Affiliations
    Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA

    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA
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  • Author Footnotes
    † These authors contributed equally.
    Sven Diederichs
    Correspondence
    Corresponding authors. Addresses: Division of Cancer Research, University Hospital Freiburg, Breisacher Str. 115, 79106 Freiburg i.Br., Germany, Tel.: +49 6221 424380 (S. Diederichs) and Department of Transplantation and Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Tel.: +1 904 956 3257 (T. Patel).
    Footnotes
    † These authors contributed equally.
    Affiliations
    Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany

    Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany

    German Cancer Consortium (DKTK), Freiburg, Germany

    Division of Cancer Research, Dept. of Thoracic Surgery, Medical Center – University of Freiburg, Freiburg, Germany

    Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Author Footnotes
    † These authors contributed equally.
    Tushar Patel
    Correspondence
    Corresponding authors. Addresses: Division of Cancer Research, University Hospital Freiburg, Breisacher Str. 115, 79106 Freiburg i.Br., Germany, Tel.: +49 6221 424380 (S. Diederichs) and Department of Transplantation and Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Tel.: +1 904 956 3257 (T. Patel).
    Footnotes
    † These authors contributed equally.
    Affiliations
    Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA

    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA
    Search for articles by this author
  • Author Footnotes
    † These authors contributed equally.
Published:April 21, 2017DOI:https://doi.org/10.1016/j.jhep.2017.04.009

      Summary

      The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

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      Keywords

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