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Molecular classification of hepatocellular adenoma in clinical practice

  • Jean-Charles Nault
    Correspondence
    Corresponding author. Address: Inserm UMR1162, APHP, Hôpitaux universitaires Paris – Seine Saint-Denis, Site Jean Verdier, Pôle d’Activité Cancérologique spécialisée, Service d’Hépatologie, 93143 Bondy, France. Tel.: +33 01 53 72 51 94; fax: +33 01 53 72 51 92.
    Affiliations
    Unité Mixte de Recherche 1162, Génomique fonctionnelle des tumeurs solides, Institut National de la Santé et de la Recherche Médicale, Paris, France

    Liver Unit, Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bondy, France

    Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris 13, Communauté d’Universités et Etablissements Sorbonne Paris Cité, Paris, France
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  • Valérie Paradis
    Affiliations
    Pathology Department, Beaujon Hospital, APHP, Clichy 92110, France

    University Paris Diderot, Sorbonne Paris Cité, Paris, France

    INSERM UMR 1149, Inflammation Research Center, Paris-Diderot University, Paris
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  • Daniel Cherqui
    Affiliations
    Hepatobiliary Centre, Paul Brousse Hospital – Université Paris Sud, Institut National de la Santé et de la Recherche Médicale U1193, 14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
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  • Valérie Vilgrain
    Affiliations
    University Paris Diderot, Sorbonne Paris Cité, Paris, France

    Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine, France

    INSERM U1149, centre de recherche biomédicale Bichat-Beaujon, CRB3 Paris, France
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  • Jessica Zucman-Rossi
    Affiliations
    Unité Mixte de Recherche 1162, Génomique fonctionnelle des tumeurs solides, Institut National de la Santé et de la Recherche Médicale, Paris, France

    Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France

    Assistance Publique-Hôpitaux de Paris, Hopital Europeen Georges Pompidou, F-75015 Paris, France
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      Summary

      Hepatocellular adenomas (HCA) are rare benign liver tumors occurring in young women taking contraception. They are associated with rare complications such as bleeding or malignant transformation into hepatocellular carcinoma. A molecular classification has divided HCA in several subgroups linked with risk factors, clinical behaviour, histological features and imaging: HNF1A inactivated HCA, Inflammatory HCA, CTNNB1 mutated HCA in exon 3, CTNNB1 mutated in exon 7 and 8 HCA, sonic hedgehog HCA and unclassified HCA. CTNNB1 mutated HCA in exon 3 and sonic hedgehog HCA have been linked with a high risk of malignant transformation and bleeding respectively. Herein, we review how molecular classification has modified our understanding of the pathophysiology and risk factors of HCA development, analysing its impact on clinical care in the field of diagnosis and therapeutic stratification.

      Keywords

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