Letter to the Editor| Volume 68, ISSUE 3, P617-618, March 2018

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Acid-base disorders in liver disease

  • Anna Teresa Mazzeo
    Department of Surgical Sciences, Anesthesia and Intensive Care, University of Turin, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Presidio Molinette, Turin, Italy
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  • Sergio Maimone
    Corresponding author. Address: Division of Clinical and Molecular Hepatology, Department of Internal Medicine, University Hospital “G. Martino” of Messina, 98124 Messina, Italy. Tel.: +39 090 2212392; fax: +39 090 2213594.
    Division of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy
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Published:October 20, 2017DOI:
      We read with great interest the article by Scheiner et al. focusing on the topic of acid-base disorders in patients with advanced liver disease.
      • Scheiner B.
      • Lindner G.
      • Reiberger T.
      • et al.
      Acid-base disorders in liver disease.

      Linked Article

      • Acid-base disorders in liver disease
        Journal of HepatologyVol. 67Issue 5
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          Alongside the kidneys and lungs, the liver has been recognised as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. While the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical–chemical acid-base model provides a more in-depth pathophysiological assessment for clinical judgement of acid-base disorders, in patients with liver diseases.
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      • Reply to: “Acid-base disorders in liver disease”
        Journal of HepatologyVol. 68Issue 3
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          We would like to thank Mazzeo and Maimone for their insightful comments on our review “Acid-base disorders in liver disease”.1 While we intentionally kept our main focus on metabolic acid-base disorders, Mazzeo and Maimone summarized the literature and shared their valuable thoughts on respiratory alterations and monitoring of the liver-lung crosstalk in critically ill patients with acute or chronic liver failure.2
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