Advertisement

Acid-base disorders in liver disease

  • Anna Teresa Mazzeo
    Affiliations
    Department of Surgical Sciences, Anesthesia and Intensive Care, University of Turin, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Presidio Molinette, Turin, Italy
    Search for articles by this author
  • Sergio Maimone
    Correspondence
    Corresponding author. Address: Division of Clinical and Molecular Hepatology, Department of Internal Medicine, University Hospital “G. Martino” of Messina, 98124 Messina, Italy. Tel.: +39 090 2212392; fax: +39 090 2213594.
    Affiliations
    Division of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy
    Search for articles by this author
Published:October 20, 2017DOI:https://doi.org/10.1016/j.jhep.2017.09.027
      We read with great interest the article by Scheiner et al. focusing on the topic of acid-base disorders in patients with advanced liver disease.
      • Scheiner B.
      • Lindner G.
      • Reiberger T.
      • et al.
      Acid-base disorders in liver disease.

      Linked Article

      • Acid-base disorders in liver disease
        Journal of HepatologyVol. 67Issue 5
        • Preview
          Alongside the kidneys and lungs, the liver has been recognised as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. While the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical–chemical acid-base model provides a more in-depth pathophysiological assessment for clinical judgement of acid-base disorders, in patients with liver diseases.
        • Full-Text
        • PDF
      • Reply to: “Acid-base disorders in liver disease”
        Journal of HepatologyVol. 68Issue 3
        • Preview
          We would like to thank Mazzeo and Maimone for their insightful comments on our review “Acid-base disorders in liver disease”.1 While we intentionally kept our main focus on metabolic acid-base disorders, Mazzeo and Maimone summarized the literature and shared their valuable thoughts on respiratory alterations and monitoring of the liver-lung crosstalk in critically ill patients with acute or chronic liver failure.2
        • Full-Text
        • PDF
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hepatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Scheiner B.
        • Lindner G.
        • Reiberger T.
        • et al.
        Acid-base disorders in liver disease.
        J Hepatol. 2017; 67: 1062-1073
        • Rodriguez-Roisin R.
        • Krowka M.J.
        Hepatopulmonary syndrome–a liver-induced lung vascular disorder.
        N Engl J Med. 2008; 358: 2378-2387
        • Krowka M.J.
        • Fallon M.B.
        • Kawut S.M.
        • et al.
        International liver transplant society practice guidelines: diagnosis and management of hepatopulmonary syndrome and portopulmonary hypertension.
        Transplantation. 2016; 100: 1440-1452
        • Audimoolam V.K.
        • McPhail M.J.
        • Wendon J.A.
        • et al.
        Lung injury and its prognostic significance in acute liver failure.
        Crit Care Med. 2014; 42: 592-600
        • Mazzeo A.T.
        • Lucanto T.
        • Santamaria L.B.
        Hepatopulmonary syndrome: a concern for the anesthetist? Pre-operative evaluation of hypoxemic patients with liver disease.
        Acta Anaesthesiol Scand. 2004; 48: 178-186
        • Gattinoni L.
        • Pesenti A.
        • Matthay M.
        Understanding blood gas analysis.
        Intensive Care Med. 2017;
        • Stark R.J.
        • Shekerdemian L.S.
        Estimating intracardiac and extracardiac shunting in the setting of complex congenital heart disease.
        Ann Pediatr Cardiol. 2013; 6: 145-151
        • Mallat J.
        • Lemyze M.
        • Tronchon L.
        • Vallet B.
        • Thevenin D.
        Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock.
        World J Crit Care Med. 2016; 5: 47-56
        • Mekontso-Dessap A.
        • Castelain V.
        • Anguel N.
        • et al.
        Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients.
        Intensive Care Med. 2002; 28: 272-277
        • Kozlov A.V.
        • Lancaster Jr., J.R.
        • Meszaros A.T.
        • Weidinger A.
        Mitochondria-meditated pathways of organ failure upon inflammation.
        Redox Biol. 2017; 13: 170-181