Hepatic encephalopathy (HE) is a major complication of liver disease that has a multi-faceted
pathophysiology.
[1]
It is associated with a substantial burden to the individual, their caregivers, society
and the overall healthcare system. The emergence of HE as a leading cause of re-admissions,
mortality and psychosocial impairment in cirrhosis should be a rallying cry to improve
its management.
[2]
The current demographic trend towards an aging population makes diagnosis challenging
and increases the burden of HE, since most older patients are not liver transplant
candidates.To read this article in full you will need to make a payment
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References
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- Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy.Hepatology. 2007; 45: 549-559
- Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF).J Hepatol. 2014; 60: 275-281
- The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus.Hepatology. 2013; 58: 325-336
- Hepatic encephalopathy expands the predictivity of model for end-stage liver disease in liver transplant setting: Evidence by means of 2 independent cohorts.Liver Transpl. 2016; 22: 1333-1342
- Persistence of cognitive impairment after resolution of overt hepatic encephalopathy.Gastroenterology. 2010; 138: 2332-2340
Article info
Publication history
Accepted:
November 1,
2017
Received in revised form:
September 27,
2017
Received:
July 13,
2017
Identification
Copyright
© 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
