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Letter to the Editor| Volume 68, ISSUE 4, P851-853, April 2018

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Stomach reduction or gastric bypass as risk factor for treatment failure after DAA therapy for hepatitis C?

Published:November 21, 2017DOI:https://doi.org/10.1016/j.jhep.2017.10.035
Stomach reduction or gastric bypass as risk factor for treatment failure after DAA therapy for hepatitis C?
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      Treatment of chronic hepatitis C virus (HCV) with direct acting antivirals (DAA) is effective in more than 95% of patients. The current European Association for the Study of the Liver treatment recommendations address all topics related to the treatment of HCV infection and provide recommendations for optimized DAA therapies based on factors associated with treatment failure such as genotype, pretreatment, cirrhosis or baseline resistance.
      European Association for the Study of the Liver
      EASL recommendations on treatment of hepatitis C 2016.
      J Hepatol. 2017; 66 (PubMed PMID: 27667367): 153-194
      Herein, we suggest that bariatric or gastric surgery leading to stomach reduction or gastric bypass may influence response to DAA treatment.

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      Linked Article

      • EASL Recommendations on Treatment of Hepatitis C 2016
        Journal of HepatologyVol. 66Issue 1
        • Preview
          Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide [1]. The long-term impact of HCV infection is highly variable, ranging from minimal histological changes to extensive fibrosis and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically infected persons worldwide is estimated to be about 180 million [2], but most are unaware of their infection. Clinical care for patients with HCV-related liver disease has advanced considerably during the last two decades, thanks to an enhanced understanding of the pathophysiology of the disease, and because of developments in diagnostic procedures and improvements in therapy and prevention.
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      Article info

      Publication history

      Published online: November 21, 2017

      Identification

      DOI: https://doi.org/10.1016/j.jhep.2017.10.035

      Copyright

      © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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