Detecting microvascular invasion in HCC with contrast-enhanced MRI: Is it a good idea?

Teh-Ia Huo; Po-Hong Liu; Chia-Yang Hsu

doi:10.1016/j.jhep.2017.11.041

Letter to the Editor| Volume 68, ISSUE 4, P862-863, April 2018

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Detecting microvascular invasion in HCC with contrast-enhanced MRI: Is it a good idea?

Teh-Ia Huo
Teh-Ia Huo
Correspondence
Corresponding author. Address: Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Tel.: +886 2 2871 2121x2050; fax: +886 2 2873 9318.
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Affiliations
Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan
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Po-Hong Liu
Po-Hong Liu
Affiliations
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
Harvard T.H. Chan School of Public Health, Boston, MA, USA
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Chia-Yang Hsu
Chia-Yang Hsu
Affiliations
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
Department of Internal Medicine, University of Nevada School of Medicine, Reno, NV, USA
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Published:December 27, 2017DOI:https://doi.org/10.1016/j.jhep.2017.11.041

We have read with interest the paper “Preoperative gadoxetic acid-enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma” by Drs. S. Lee et al. published in a recent issue of the Journal of Hepatology.

^[1]

Lee S.
Kim S.H.
Lee J.E.
Sinn D.H.
Park C.K.

Preoperative gadoxetic acid-enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma.

This study clearly described the feasibility of contrast-enhanced MRI by using gadoxetic acid to detect microvascular invasion (mVI) in a surgical cohort of patients with hepatocellular carcinoma (HCC) ≤5 cm in diameter. Although their findings highlight the role of contrast-enhanced MRI for small HCC, a few concerns may need attention to justify its usefulness in clinical practice.

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Preoperative gadoxetic acid–enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma
Journal of HepatologyVol. 67Issue 3
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  Vascular invasion, either macrovascular or microvascular invasion (MVI), is a well-known major prognostic factor of hepatocellular carcinoma (HCC), after surgical resection or liver transplantation.^1–4 In particular, MVI of HCC is a major risk factor for early recurrence during the first 2 years after curative treatment.^5,6 Although macrovascular invasion can be frequently detected prior to surgery by complementary imaging modalities, including computed tomography (CT) and magnetic resonance (MR) imaging, MVI can rarely be determined preoperatively because it is a histopathological diagnosis.
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Reply to: “Detecting microvascular invasion in HCC with contrast-enhanced MRI: Is it a good idea?”
Journal of HepatologyVol. 68Issue 4
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  We thank Teh-Ia Huo et al. for their interest in our recent study about preoperative gadoxetic acid–enhanced MRI for predicting microvascular invasion (MVI) in patients with single hepatocellular carcinoma (HCC),¹ and we appreciate their comments.
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References

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Preoperative gadoxetic acid-enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma.
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Published online: December 27, 2017

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DOI: https://doi.org/10.1016/j.jhep.2017.11.041

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Detecting microvascular invasion in HCC with contrast-enhanced MRI: Is it a good idea?

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