Advertisement
Editorial| Volume 68, ISSUE 4, P635-637, April 2018

Download started.

Ok

Interfering with Kupffer cell replenishment: New insights into liver injury

  • William Alazawi
    Correspondence
    Corresponding author. Address: Barts Liver Centre, Blizard Insti, 4 Newark Street, London E1 2AT, United Kingdom. Tel.: +44 7882 7195.
    Affiliations
    Barts Liver Centre, Blizard Institute, Queen Mary, University of London, London, United Kingdom
    Search for articles by this author
  • Percy A. Knolle
    Affiliations
    Institute of Molecular Immunology/Experimental Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany
    Search for articles by this author
Published:February 17, 2018DOI:https://doi.org/10.1016/j.jhep.2018.01.011
      Interferon (IFN) has slipped off the hepatology radar in recent years, but a study by Borst and colleagues in this issue of Journal of Hepatology, reminds us that IFN signalling is an integral component of the liver’s highly coordinated response to viral infection and tissue injury.

      Linked Article

      • Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis
        Journal of HepatologyVol. 68Issue 4
        • Preview
          Many different viral infections can cause acute hepatitis that may result in acute liver failure. Besides infections with hepatotropic virus (e.g., hepatitis B virus and hepatitis C virus) other viruses such as cytomegalovirus (CMV) can cause acute hepatitis.1–5 Yet, it is unclear to what extent viral pathogenicity or immunopathology cause liver damage. The liver is the central metabolic organ, which is characterized by a tolerogenic environment. Hepatic sinusoids are populated with antigen-presenting cells such as Kupffer cells (KC).
        • Full-Text
        • PDF
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hepatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Mass E.
        • Ballesteros I.
        • Farlik M.
        • Halbritter F.
        • Gunther P.
        • Crozet L.
        • et al.
        Specification of tissue-resident macrophages during organogenesis.
        Science. 2016; 353
        • Scott C.L.
        • Zheng F.
        • De Baetselier P.
        • Martens L.
        • Saeys Y.
        • De Prijck S.
        • et al.
        Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.
        Nat Commun. 2016; 7: 10321
        • Krenkel O.
        • Tacke F.
        Liver macrophages in tissue homeostasis and disease.
        Nat Rev Immunol. 2017; 17: 306-321
        • Gomez Perdiguero E.
        • Klapproth K.
        • Schulz C.
        • Busch K.
        • Azzoni E.
        • Crozet L.
        • et al.
        Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.
        Nature. 2015; 518: 547-551
        • Borst K.
        • Frenz T.
        • Spanier J.
        • Tegtmeyer P.-K.
        • Chlatbar C.
        • Skerra J.
        • et al.
        Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.
        J Hepatol. 2018; 68: 682-690
        • Lang P.A.
        • Recher M.
        • Honke N.
        • Scheu S.
        • Borkens S.
        • Gailus N.
        • et al.
        Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.
        Hepatology. 2010; 52: 25-32
        • Sitia G.
        • Iannacone M.
        • Aiolfi R.
        • Isogawa M.
        • van Rooijen N.
        • Scozzesi C.
        • et al.
        Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.
        PLoS Pathog. 2011; 7: e1002061
        • Bleriot C.
        • Dupuis T.
        • Jouvion G.
        • Eberl G.
        • Disson O.
        • Lecuit M.
        Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.
        Immunity. 2015; 42: 145-158
        • Conrad E.
        • Resch T.K.
        • Gogesch P.
        • Kalinke U.
        • Bechmann I.
        • Bogdan C.
        • et al.
        Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice.
        Hepatology. 2014; 59: 1555-1563
        • Sander J.
        • Schmidt S.V.
        • Cirovic B.
        • McGovern N.
        • Papantonopoulou O.
        • Hardt A.L.
        • et al.
        Cellular differentiation of human monocytes is regulated by time-dependent interleukin-4 signaling and the transcriptional regulator NCOR2.
        Immunity. 2017; 47 (e1012): 1051-1066
        • Hackstein C.P.
        • Assmus L.M.
        • Welz M.
        • Klein S.
        • Schwandt T.
        • Schultze J.
        • et al.
        Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
        Gut. 2017; 66: 507-518
        • Weiss E.
        • Rautou P.E.
        • Fasseu M.
        • Giabicani M.
        • de Chambrun M.
        • Wan J.
        • et al.
        Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
        J Hepatol. 2017; 66: 930-941