- •Binge alcohol exposure caused apoptosis of gut enterocytes in rats and WT mice.
- •Binge alcohol exposure reduced the levels of tight junction and adherent junction proteins.
- •Nitration of the junctional proteins led to ubiquitin-dependent degradation.
- •Apoptosis of enterocytes and reduced junctional proteins led to gut leakiness.
- •Binge alcohol-induced gut leakiness was observed in mice, rats and humans.
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