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Prevalent acute-on-chronic liver failure and response to corticosteroids in alcoholic hepatitis

Published:August 24, 2018DOI:https://doi.org/10.1016/j.jhep.2018.06.019
      We read the paper by Sersté et al. regarding the significance of acute-on-chronic liver failure (ACLF) in alcoholic hepatitis (AH) with interest.
      • Sersté T.
      • Cornillie A.
      • Njimi H.
      • Pavesi M.
      • Arroyo V.
      • Putignano A.
      • et al.
      The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis.
      They conclude that ACLF in AH is associated with a poor outcome and that the Lille response to corticosteroids was reduced in those with prevalent ACLF.
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      References

        • Sersté T.
        • Cornillie A.
        • Njimi H.
        • Pavesi M.
        • Arroyo V.
        • Putignano A.
        • et al.
        The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis.
        J Hepatol. 2018; 69: 318-324
        • Forrest E.H.
        • Atkinson S.R.
        • Richardson P.
        • Masson S.
        • Ryder S.
        • Thursz M.
        • et al.
        Application of prognostic scores in the STOPAH trial: discriminant function is no longer the optimal scoring system in alcoholic hepatitis.
        J Hepatol. 2018; 68: 511-518
        • Arroyo V.
        • Moreau R.
        • Jalan R.
        • Ginès P.
        • EASL-CLIF Consortium CANONIC Study
        Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis.
        J Hepatol. 2015; 62: 131-143

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