- •Comparative analysis of 18,498 initiators of PI-based DAAs matched on propensity score to 18,498 initiators of non-PI-based DAAs to assess risk of three acute liver injury endpoints, according to advanced hepatic fibrosis/cirrhosis status by FIB-4.
- •Propensity score-matched hazard ratios of ALT >200 U/L were higher for PI than non-PI initiators in those with and without baseline advanced hepatic fibrosis/cirrhosis (i.e., FIB-4 >3.25 and FIB-4 ≤3.25, respectively).
- •No differences in propensity score-matched hazard ratios of severe hepatic dysfunction or hepatic decompensation were observed between PI and non-PI-based DAA initiators, regardless of baseline advanced hepatic fibrosis/cirrhosis status by FIB-4.
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