- •Stable cell lines producing high-titer cell culture-generated HBV of various genotypes were established.
- •HBV genotypes showed stable infectivity in both in vitro and in vivo models.
- •HBV genotypes exhibit different infectivity, antigen expression, replication and responses to treatment.
- •These model systems are valuable tools for antiviral development.
Background & Aims
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Author names in bold designate shared co-first authorship