Acute kidney disease (AKD) is the persistence of acute kidney injury (AKI) for up to 3 months. In this study, Patidar and coworkers
aimed to define the incidence and outcomes associated with AKD in a nationwide US cohort (n = 6,250) of hospitalised patients with cirrhosis and AKI. KDIGO and ADQI-AKD and Renal-Recovery consensus criteria were used to define AKI and AKD, respectively. The primary outcome was mortality; the secondary outcome was de novo
development of chronic kidney disease (CKD). Competing-risk multivariable models were used to determine the independent association of AKD with primary and secondary outcomes. AKD developed in 32% of patients.
On multivariable competing risk analysis adjusting for significant confounders, patients with AKD had higher risk of mortality at 90 and 180 days.
The incidence of de novo
CKD was 37.5% and patients with AKD had higher rates of de novo
CKD than patients without AKD (64.0% vs.
30.7%). AKD was independently associated with de novo