- •Currently there is no finite cure for chronic hepatitis B virus (HBV) infection.
- •Combination therapy with immune modulators and other HBV-specific agents are being explored.
- •The immune modulator selgantolimod is an oral agonist of toll-like receptor 8 (TLR8).
- •Selgantolimod once-weekly was given to chronic HBV patients for 6 months.
- •Six months after treatment, a minority had serologic changes seen with durable cure.
Background & Aims
Abbreviations:AASLD (American Association for the Study of Liver Diseases), CCL (chemokine (C-C motif) ligand), CD (cluster of differentiation), CI (confidence interval), CV (coefficient of variation), FDR (false discovery rate), HBeAg (hepatitis B e antigen), HBsAg (hepatitis B virus surface antigen), HBV (hepatitis B virus), IFN (interferon), IL (interleukin), IL-1RA (interleukin-1 receptor antagonist), IQR (interquartile range), NK cells (natural-killer cells), OR (odds ratio), PBMC (peripheral blood mononuclear cell), SD (standard deviation), SF (superfamily), TNF (tumor necrosis factor), TNFSF (TNF superfamily), TLR (toll-like receptor), ULN (upper limit of normal)
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