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Abstract
Background/Aims: The incidence of obese patients with fatty liver has recently increased in Japan
as well as in the United States and Europe. Fatty liver may occasionally progress
to liver cirrhosis. In this study, we have compared the effects of restricted diet
and exercise versus no treatment in obese patients with fatty liver.
Methods: Twenty-five obese patients with fatty liver were divided into treated and control
groups. Fifteen obese patients followed a program of restricted diet (ideal weight
· 25 Cal · kg−1) and exercise (walking or jogging) for a trial period of 3 months. No changes in
diet or lifestyle were made by the other 10 patients during the same trial period.
Blood biochemical tests and liver histology were compared in all patients before and
after the trial.
Results: In the treated group, weight, blood biochemical data such as aminotransferase, albumin,
cholinesterase, total cholesterol and fasting blood glucose values, and steatosis
were significantly decreased after the trial. In the control group, there were no
significant differences in the clinical and histological findings before and after
the trial.
Conclusions: These results indicate that restricted diet and exercise therapy, such as walking
and jogging, are useful means of improving blood biochemical data and histological
findings in liver tissues related to fatty liver.
Keywords
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References
- Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.Circulation. 1983; 67: 968-977
- Health implications of overweight and obesity in the Unites States.Ann Intern Med. 1985; 103: 983-988
- Nutritional and metabolic liver disease.in: Sherlock S Dooley J 9th edn. Diseases of the liver and biliary system. 408-433. Blackwell Scientific Publications, London1993
- Nonalcoholic fatty liver.in: Haubrich WS Schaffner F Berk JE 5th edn. Gastroenterology. W.B. Saunders, Philadelphia1995: 2246-2254
- Fatty liver hepatitis (steatopatitis) and obesity: an autopsy study with analysis of risk factors.Hepatology. 1990; 12: 1106-1110
- Fatty liver hepatitis and cirrhosis in obese patients.Am J Med. 1979; 67: 811-816
- Five patients with nonalcoholic diabetic cirrhosis.Acta Hepato-Gastroenterol. 1979; 26: 90-97
- Nonalcoholic steatohepatitis.Mayo Clin Proc. 1980; 55: 434-438
- Nonalcoholic steatohepatitis: a study of 49 patients.Hum Pathol. 1989; 20: 594-598
- The natural history of nonalcoholic steatohepatitis: a follow-up study of 42 patients for up to 21 years.Hepatology. 1990; 11: 74-80
- Nonalcoholic steatohepatitis: an expanded clinical entity.Gastroenterology. 1994; 107: 1103-1109
- Benefits and risks of an intensive very-low-calorie diet program for severe obesity.Am J Gastroenterol. 1992; 87: 6-15
- Very-low-calorie-diet therapy in severe obesity.Am J Clin Nutr. 1992; 56: 299S-302S
- Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period.Am J Clin Nutr. 1993; 57: 35-42
- Severe vs moderate energy restriction with and without exercise in the treatment of obesity: efficiency of weight loss.Am J Clin Nutr. 1993; 57: 127-134
- Indices of relative weight and obesity.J Chon Dis. 1972; 25: 329-343
- Effects of weight changes produced by exercise, food restriction, or overeating on body composition.J Clin Invest. 1969; 48: 2124-2128
- Physical training of obese middle-aged persons.Ann Clin Res. 1982; 34 (Suppl): 80-85
- Alcohol like liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.Gastroenterology. 1988; 95: 1056-1062
- aEffect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass.N Engl J Med. 1970; 282: 829-834
- bDiagnostic value of the fibrosis of the terminal hepatic venule in fatty liver and chronic hepatitis due to ethanol or other aetiology.Liver. 1985; 5: 261-266
- Hepatic free fatty acids in alcoholic liver disease and morbid obesity.Hepatology. 1983; 3: 226-231
- Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis.J Gastroenterol Hepatol. 1991; 6: 585-590
Article info
Publication history
Accepted:
February 13,
1997
Received in revised form:
February 3,
1997
Received:
July 23,
1996
Identification
Copyright
© 1997 European Association for the study of the Liver. Published by Elsevier Inc. All rights reserved.
