Research Article| Volume 27, ISSUE 1, P103-107, July 1997

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Therapeutic effects of restricted diet and exercise in obese patients with fatty liver

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      Background/Aims: The incidence of obese patients with fatty liver has recently increased in Japan as well as in the United States and Europe. Fatty liver may occasionally progress to liver cirrhosis. In this study, we have compared the effects of restricted diet and exercise versus no treatment in obese patients with fatty liver.
      Methods: Twenty-five obese patients with fatty liver were divided into treated and control groups. Fifteen obese patients followed a program of restricted diet (ideal weight · 25 Cal · kg−1) and exercise (walking or jogging) for a trial period of 3 months. No changes in diet or lifestyle were made by the other 10 patients during the same trial period. Blood biochemical tests and liver histology were compared in all patients before and after the trial.
      Results: In the treated group, weight, blood biochemical data such as aminotransferase, albumin, cholinesterase, total cholesterol and fasting blood glucose values, and steatosis were significantly decreased after the trial. In the control group, there were no significant differences in the clinical and histological findings before and after the trial.
      Conclusions: These results indicate that restricted diet and exercise therapy, such as walking and jogging, are useful means of improving blood biochemical data and histological findings in liver tissues related to fatty liver.


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        • Hubert HB
        • Feinleib M
        • McNamara PM
        • Castelli WP
        Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
        Circulation. 1983; 67: 968-977
        • Van Itallie TB
        Health implications of overweight and obesity in the Unites States.
        Ann Intern Med. 1985; 103: 983-988
        • Sherlock S
        • Dooley J
        Nutritional and metabolic liver disease.
        in: Sherlock S Dooley J 9th edn. Diseases of the liver and biliary system. 408-433. Blackwell Scientific Publications, London1993
        • Schaffner F
        Nonalcoholic fatty liver.
        in: Haubrich WS Schaffner F Berk JE 5th edn. Gastroenterology. W.B. Saunders, Philadelphia1995: 2246-2254
        • Wanless IR
        • Lentz JS
        Fatty liver hepatitis (steatopatitis) and obesity: an autopsy study with analysis of risk factors.
        Hepatology. 1990; 12: 1106-1110
        • Adler M
        • Schaffner F
        Fatty liver hepatitis and cirrhosis in obese patients.
        Am J Med. 1979; 67: 811-816
        • Ito S
        • Tsukada Y
        • Motomura Y
        • Ichinoe A
        Five patients with nonalcoholic diabetic cirrhosis.
        Acta Hepato-Gastroenterol. 1979; 26: 90-97
        • Ludwig J
        • Viggiano TR
        • Mcgill DB
        • Ott BJ
        Nonalcoholic steatohepatitis.
        Mayo Clin Proc. 1980; 55: 434-438
        • Lee RG
        Nonalcoholic steatohepatitis: a study of 49 patients.
        Hum Pathol. 1989; 20: 594-598
        • Powell EE
        • Cooksley GE
        • Hanson R
        • Searle J
        • Halliday JW
        • Powell LW
        The natural history of nonalcoholic steatohepatitis: a follow-up study of 42 patients for up to 21 years.
        Hepatology. 1990; 11: 74-80
        • Bacon BR
        • Farahvash MJ
        • Janney CG
        • Neuschwander-Tetri BA
        Nonalcoholic steatohepatitis: an expanded clinical entity.
        Gastroenterology. 1994; 107: 1103-1109
        • Anderson JW
        • Hamilton CC
        • Brinkman-Kaplan V
        Benefits and risks of an intensive very-low-calorie diet program for severe obesity.
        Am J Gastroenterol. 1992; 87: 6-15
        • Yamamoto R
        • Inoue S
        • Saito M
        • Okamoto M
        • Okamura A
        • Takamura Y
        Very-low-calorie-diet therapy in severe obesity.
        Am J Clin Nutr. 1992; 56: 299S-302S
        • Froidevaux F
        • Schutz Y
        • Christin L
        • Jéquier E
        Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period.
        Am J Clin Nutr. 1993; 57: 35-42
        • Sweeney ME
        • Hill JO
        • Heller PA
        • Baney R
        • DiGirolamo M
        Severe vs moderate energy restriction with and without exercise in the treatment of obesity: efficiency of weight loss.
        Am J Clin Nutr. 1993; 57: 127-134
        • Keys A
        • Fidanza F
        • Karvonen MJ
        • Kimura N
        • Taylor HL
        Indices of relative weight and obesity.
        J Chon Dis. 1972; 25: 329-343
        • Oscai LB
        • Holloszy JO
        Effects of weight changes produced by exercise, food restriction, or overeating on body composition.
        J Clin Invest. 1969; 48: 2124-2128
        • Kukkonen K
        • Rauramaa R
        • Siitonen O
        • Hänninen O
        Physical training of obese middle-aged persons.
        Ann Clin Res. 1982; 34 (Suppl): 80-85
        • Diehl AM
        • Goodman Z
        • Ishak KG
        Alcohol like liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.
        Gastroenterology. 1988; 95: 1056-1062
      1. a
        • Drenick EJ
        • Simmons F
        • Murphy JF
        Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass.
        N Engl J Med. 1970; 282: 829-834
      2. b
        • Brunelli E
        • Maccarri G
        • Jezequel AM
        • Orlandi F
        Diagnostic value of the fibrosis of the terminal hepatic venule in fatty liver and chronic hepatitis due to ethanol or other aetiology.
        Liver. 1985; 5: 261-266
        • Mavrelis PG
        • Ammon HV
        • Gleysteen JJ
        • Komorowski RA
        • Charaf UK
        Hepatic free fatty acids in alcoholic liver disease and morbid obesity.
        Hepatology. 1983; 3: 226-231
        • Fiatarone JR
        • Coverdale SA
        • Batey RG
        • Farrell GC
        Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis.
        J Gastroenterol Hepatol. 1991; 6: 585-590