Pol and his colleagues (
1.) have added an important piece to the available data regarding the issue of the natural history of liver disease in HIV/HCV-coinfected patients. Instead of using debatable endpoints such as “liver failure” (
- Pol S
- Lamorthe B
- Thi NT
- Thiers V
- Carnot F
- Zylberberg H
- et al.
Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users.
J Hepatol. 1998; 28: 45-50
- Eyster ME
- Diamondstone LS
- Lien JM
- Ehmann C
- Quan S
- Goedert JJ
Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus.
J AIDS. 1993; 6: 602-610
3.), they have looked, although retrospectively, at histological cirrhosis. Using multivariable analysis, and having a sufficient number of dependent variables (41 cases of cirrhosis), they demonstrate that both excessive drinking and HIV infection are independently associated with the finding of cirrhosis in HCV-infected injection drug users. However, there are a few caveats in the interpretation of their results.
- Telfer P
- Sabin C
- Devereux H
- Scott F
- Dusheiko G
- Lee C
The progression of HCV-associated liver disease in a cohort of haemophilic patients.
Br J Haematol. 1994; 87: 555
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Hepatology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users.J Hepatol. 1998; 28: 45-50
- Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus.J AIDS. 1993; 6: 602-610
- The progression of HCV-associated liver disease in a cohort of haemophilic patients.Br J Haematol. 1994; 87: 555
- Influence of hepatitis C genotypes and HIV infection on histological severity of chronic hepatitis C.Am J Gastroenterol. 1997; 92: 1130-1134
- Human immunodeficiency virus infection modifies the natural history of chronic parenterally acquired hepatitis C with an unusually rapid progression to cirrhosis.J Hepatol. 1997; 26: 1-5
- Impact of treatment with HIV protease inhibitors on hepatitis C viremia in patients coinfected with HIV.J Infect Dis. 1998; 177: 783-785
© 1999 Published by Elsevier Inc.