Pol and his colleagues (
1.
) have added an important piece to the available data regarding the issue of the natural
history of liver disease in HIV/HCV-coinfected patients. Instead of using debatable
endpoints such as “liver failure” (
2.
,
3.
), they have looked, although retrospectively, at histological cirrhosis. Using multivariable
analysis, and having a sufficient number of dependent variables (41 cases of cirrhosis),
they demonstrate that both excessive drinking and HIV infection are independently associated with the finding
of cirrhosis in HCV-infected injection drug users. However, there are a few caveats
in the interpretation of their results.To read this article in full you will need to make a payment
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References
- Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users.J Hepatol. 1998; 28: 45-50
- Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus.J AIDS. 1993; 6: 602-610
- The progression of HCV-associated liver disease in a cohort of haemophilic patients.Br J Haematol. 1994; 87: 555
- Influence of hepatitis C genotypes and HIV infection on histological severity of chronic hepatitis C.Am J Gastroenterol. 1997; 92: 1130-1134
- Human immunodeficiency virus infection modifies the natural history of chronic parenterally acquired hepatitis C with an unusually rapid progression to cirrhosis.J Hepatol. 1997; 26: 1-5
- Impact of treatment with HIV protease inhibitors on hepatitis C viremia in patients coinfected with HIV.J Infect Dis. 1998; 177: 783-785
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© 1999 Published by Elsevier Inc.
