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Letter to the Editor| Volume 77, ISSUE 6, P1721-1722, December 2022

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Reply to: “External validation of a genetic risk score that predicts development of alcohol-related cirrhosis”

John B. Whitfield
John B. Whitfield
Affiliations
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Queensland 4029, Australia
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Timothy R. Morgan
Timothy R. Morgan
Affiliations
Department of Medicine, University of California, Irvine, USA
Department of Veterans Affairs, VA Long Beach Healthcare System, 5901 East Seventh Street, Long Beach, CA 90822, USA
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Devanshi Seth
Devanshi Seth
Correspondence
Corresponding author. Address: Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW 2006, Australia; Tel.: +61 95656268, fax: +61 95656101.
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Affiliations
Edith Collins Centre (Translational Research in Alcohol Drugs and Toxicology), Sydney Local Health District, Missenden Road, Camperdown, NSW 2050, Australia
Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia
Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW 2006, Australia
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Published:August 30, 2022DOI:https://doi.org/10.1016/j.jhep.2022.08.024

Thank you for the opportunity to respond to the letter from Johansen et al.,

^[1]

Johansen S.
Thiele M.
Juel H.B.
Hansen T.
Krag A.

External validation of a genetic risk score that predicts development of alcohol-related cirrhosis.

extending our earlier findings reported in the Journal.

^[2]

Whitfield J.B.
Schwantes-An T.H.
Darlay R.
Aithal G.P.
Atkinson S.R.
Bataller R.
et al.

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

Linked Article

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers
Journal of HepatologyVol. 76Issue 2
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  Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk.
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External validation of a genetic risk score that predicts development of alcohol-related cirrhosis
Journal of HepatologyVol. 77Issue 6
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  We read with great interest the article by Whitfield et al. on the development of a score that combines genetic risk variants in 3 genes (PNPLA3, TM6SF2, HSD17B13) and presence of diabetes to stratify heavy drinkers based on their risk of cirrhosis.¹ The authors evaluated the risk score in cohorts of patients with an alcohol consumption exceeding 80 g/day for men or 50 g/day for women for 10 years or more. We sought to validate their results by evaluating the score in an independent Danish cohort of 439 patients with a history of excessive alcohol use, but at lower levels of heavy drinking than in the 3 cohorts from Whitfield et al.
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References

- Johansen S.
- Thiele M.
- Juel H.B.
- Hansen T.
- Krag A.
External validation of a genetic risk score that predicts development of alcohol-related cirrhosis.
J Hepatol. 2022; 77: 1720-1721https://doi.org/10.1016/j.jhep.2022.06.006
View in Article
- Whitfield J.B.
- Schwantes-An T.H.
- Darlay R.
- Aithal G.P.
- Atkinson S.R.
- Bataller R.
- et al.
A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.
J Hepatol. 2022; 76: 275-282
View in Article
- Khera A.V.
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Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.
Nat Med. 2020; 26: 549-557
View in Article
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View in Article

Article info

Publication history

Published online: August 30, 2022

Accepted: August 11, 2022

Received: July 31, 2022

Identification

DOI: https://doi.org/10.1016/j.jhep.2022.08.024

Copyright

© 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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