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Life’s Essential 8 and MAFLD in the United States

  • Xinyu Wang
    Affiliations
    Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing 100191, China
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  • Aruna Wang
    Affiliations
    Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing 100191, China
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  • Ruosu Zhang
    Affiliations
    Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing 100191, China
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  • Si Cheng
    Affiliations
    Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing 100191, China
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  • Yuanjie Pang
    Correspondence
    Corresponding author. Address: Dept. of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100191, China. Tel.: 86-010-82801528, fax: 86-010-82801530.
    Affiliations
    Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing 100191, China
    Search for articles by this author
Published:October 25, 2022DOI:https://doi.org/10.1016/j.jhep.2022.10.014
      The American Heart Association (AHA) recently proposed Life’s Essential 8 (LE8) as an update of Life’s Simple 7 (LS7) to quantify cardiovascular health (CVH), which included five health behaviors (nicotine exposure, physical activity, diet, body mass index, and sleep health) and three health factors (blood lipids, blood pressure, and blood glucose).
      • Lloyd-Jones D.M.
      • Allen N.B.
      • Anderson C.A.M.
      • Black T.
      • Brewer L.C.
      • Foraker R.E.
      • et al.
      Life’s Essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association.
      By adding a new sleep metric and being redefined on a more continuous scale, LE8 better reflects recent clinical guidelines, interindividual difference and intraindividual change than LS7.
      • Lloyd-Jones D.M.
      • Allen N.B.
      • Anderson C.A.M.
      • Black T.
      • Brewer L.C.
      • Foraker R.E.
      • et al.
      Life’s Essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association.
      Previous studies have reported associations between LS7 and cardiometabolic disease (e.g., cardiovascular disease [CVD] and diabetes).
      • Fretts A.M.
      • Howard B.V.
      • McKnight B.
      • Duncan G.E.
      • Beresford S.A.A.
      • Mete M.
      • et al.
      Life’s Simple 7 and incidence of diabetes among American Indians: the strong Heart family study.
      ,
      • Younus A.
      • Aneni E.C.
      • Spatz E.S.
      • Osondu C.U.
      • Roberson L.
      • Ogunmoroti O.
      • et al.
      A systematic review of the prevalence and outcomes of ideal cardiovascular health in US and Non-US populations.
      Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed nomenclature that has been reported to be associated with increased all-cause and cardiovascular mortality, and those with advanced fibrosis have higher risk of all-cause mortality compared to those without.
      • Kim D.
      • Konyn P.
      • Sandhu K.K.
      • Dennis B.B.
      • Cheung A.C.
      • Ahmed A.
      Metabolic dysfunction-associated fatty liver disease is associated with increased all-cause mortality in the United States.
      Since MAFLD shared similar lifestyle and metabolic risk factors with CVD, we aimed to investigate the associations of LE8 with MAFLD and clinically significant fibrosis (CSF) in participants with MAFLD.

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