Advertisement

New cell-based approaches for liver disorders: From experimental to validated clinical treatment

  • Roberto Gramignoli
    Correspondence
    Corresponding author. Address: Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.
    Affiliations
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden
    Search for articles by this author
Published:October 28, 2022DOI:https://doi.org/10.1016/j.jhep.2022.10.017
      See Article, pages 165–179

      Linked Article

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hepatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Mito M.
        • Kusano M.
        • Kawaura Y.
        Hepatocyte transplantation in man.
        Transpl Proc. 1992; 24: 3052-3053
        • Strom S.C.
        • Fisher R.A.
        • Thompson M.T.
        • Sanyal A.J.
        • Cole P.E.
        • Ham J.M.
        • et al.
        Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure.
        Transplantation. 1997; 63: 559-569
        • Gramignoli R.
        • Vosough M.
        • Kannisto K.
        • Srinivasan R.C.
        • Strom S.C.
        Clinical hepatocyte transplantation: practical limits and possible solutions.
        Eur Surg Res. 2015; 54: 162-177
        • Gramignoli R.
        • Tahan V.
        • Dorko K.
        • Venkataramanan R.
        • Fox I.J.
        • Ellis E.C.
        • et al.
        Rapid and sensitive assessment of human hepatocyte functions.
        Cel Transpl. 2014; 23: 1545-1556
        • Tolosa L.
        • Bonora-Centelles A.
        • Teresa Donato M.
        • Pareja E.
        • Negro A.
        • Lopez S.
        • et al.
        Steatotic liver: a suitable source for the isolation of hepatic progenitor cells.
        Liver Int : official J Int Assoc Study Liver. 2011; 31: 1231-1238
        • Gramignoli R.
        • Green M.L.
        • Tahan V.
        • Dorko K.
        • Skvorak K.J.
        • Marongiu F.
        • et al.
        Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation.
        Cel Transpl. 2012; 21: 1245-1260
        • Gramignoli R.
        • Tahan V.
        • Dorko K.
        • Skvorak K.J.
        • Hansel M.C.
        • Zhao W.
        • et al.
        New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.
        Stem Cel Res. 2013; 11: 563-573
        • Giancotti A.
        • Monti M.
        • Nevi L.
        • Safarikia S.
        • D’Ambrosio V.
        • Brunelli R.
        • et al.
        Functions and the emerging role of the foetal liver into regenerative medicine.
        Cells. 2019; 8: 914
        • Bluhme E.
        • Henckel E.
        • Gramignoli R.
        • Kjellin T.
        • Hammarstedt C.
        • Nowak G.
        • et al.
        Procurement and evaluation of hepatocytes for transplantation from neonatal donors after circulatory death.
        Cel Transpl. 2022; 319636897211069900
        • Zabulica M.
        • Srinivasan R.C.
        • Vosough M.
        • Hammarstedt C.
        • Wu T.
        • Gramignoli R.
        • et al.
        Guide to the assessment of mature liver gene expression in stem cell-derived hepatocytes.
        Stem Cell Dev. 2019; 28: 907-919
        • Turner R.
        • Lozoya O.
        • Wang Y.
        • Cardinale V.
        • Gaudio E.
        • Alpini G.
        • et al.
        Human hepatic stem cell and maturational liver lineage biology.
        Hepatology. 2011; 53: 1035-1045
        • Cooper S.
        • Bennett W.
        • Andrade J.
        • Reubinoff B.E.
        • Thomson J.
        • Pera M.F.
        Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells.
        J Anat. 2002; 200: 259-265
        • Cardinale V.
        • Carpino G.
        • Overi D.
        • Safarikia S.
        • Zhang W.
        • Kanke M.
        • et al.
        Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential.
        J Hepatol. 2022; 78https://doi.org/10.1016/j.jhep.2022.08.037
        • Gupta S.
        • Rajvanshi P.
        • Lee C.D.
        Integration of transplanted hepatocytes into host liver plates demonstrated with dipeptidyl peptidase iv-deficient rats.
        Proc Natl Acad Sci United States America. 1995; 92: 5860-5864
        • Bohnen N.I.
        • Charron M.
        • Reyes J.
        • Rubinstein W.
        • Strom S.C.
        • Swanson D.
        • et al.
        Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion.
        Clin Nucl Med. 2000; 25: 447-450
        • Gramignoli R.
        • Tahan V.
        • Dorko K.
        • Venkataramanan R.
        • Fox I.J.
        • Ellis E.C.
        • et al.
        Rapid-and-sensitive assessment of human hepatocyte functions.
        Cel Transplant. 2014; 23: 1545-1556
        • Bonora-Centelles A.
        • Donato M.T.
        • Lahoz A.
        • Pareja E.
        • Mir J.
        • Castell J.V.
        • et al.
        Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor.
        Cel Transplant. 2010; 19: 21-28