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Cases of severe acute liver injury following inactivated SARS-CoV-2 vaccination

Published:November 06, 2022DOI:https://doi.org/10.1016/j.jhep.2022.10.026
      Several cases of severe acute liver injury (ALI) with features of autoimmune hepatitis after SARS-CoV-2 infection or SARS-CoV-2 vaccination have been described.
      • Efe C.
      • Kulkarni A.V.
      • Terziroli Beretta-Piccoli B.
      • Magro B.
      • Stättermayer A.
      • Cengiz M.
      • et al.
      • Efe C.
      • Dhanasekaran R.
      • Lammert C.
      • Ebik B.
      • Higuera-de la Tijera F.
      • Aloman C.
      • et al.
      Outcome of COVID-19 in patients with autoimmune hepatitis: an international multicenter study.
      • Marjot T.
      • Eberhardt C.S.
      • Boettler T.
      • Belli L.S.
      • Berenguer M.
      • Buti M.
      • et al.
      Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: an updated EASL position paper.
      • Kabaçam G.
      • Wahlin S.
      • Efe C.
      Autoimmune hepatitis triggered by COVID-19: a report of two cases.
      • Codoni G.
      • Kirchner T.
      • Engel B.
      • Villamil A.M.
      • Efe C.
      • Stättermayer A.F.
      • et al.
      Histological and serological features of acute liver injury after SARS-CoV-2 vaccination.
      • Kulkarni A.V.
      • Vasireddy S.
      • Sharma M.
      • Reddy N.D.
      • Padaki N.R.
      COVID-19 masquerading as autoimmune hepatitis (AIH) flare-the first report.
      • Patel A.H.
      • Amin R.
      • Lalos A.T.
      Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination.
      Most cases developed ALI following mRNA or viral vector-based vaccines, while only a few reports described the development of ALI after inactivated SARS-CoV-2 vaccines.
      • Efe C.
      • Kulkarni A.V.
      • Terziroli Beretta-Piccoli B.
      • Magro B.
      • Stättermayer A.
      • Cengiz M.
      • et al.
      Recently, Wong et al.
      • Wong C.K.H.
      • Mak L.Y.
      • Au I.C.H.
      • Lai F.T.T.
      • Li X.
      • Wan E.Y.F.
      • et al.
      Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines.
      evaluated the risk of ALI in a large cohort of vaccine recipients. They reported that the risk of ALI did not increase due to any formulation of SARS-CoV-2 vaccination. We reviewed our cohort of patients who developed ALI after inactivated SARS-CoV-2 vaccination.

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