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Journal of Hepatology
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Letter to the Editor| Volume 78, ISSUE 2, e60-e61, February 2023

Cases of severe acute liver injury following inactivated SARS-CoV-2 vaccination

Published:November 06, 2022DOI:https://doi.org/10.1016/j.jhep.2022.10.026
Cases of severe acute liver injury following inactivated SARS-CoV-2 vaccination
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      Several cases of severe acute liver injury (ALI) with features of autoimmune hepatitis after SARS-CoV-2 infection or SARS-CoV-2 vaccination have been described.
      • Efe C.
      • Kulkarni A.V.
      • Terziroli Beretta-Piccoli B.
      • Magro B.
      • Stättermayer A.
      • Cengiz M.
      • et al.
      Hepatology. 2022; (10.1002/hep.32572)https://doi.org/10.1002/hep.32572
      , 
      • Efe C.
      • Dhanasekaran R.
      • Lammert C.
      • Ebik B.
      • Higuera-de la Tijera F.
      • Aloman C.
      • et al.
      Outcome of COVID-19 in patients with autoimmune hepatitis: an international multicenter study.
      Hepatology. 2022; 76: 1576-1586
      , 
      • Marjot T.
      • Eberhardt C.S.
      • Boettler T.
      • Belli L.S.
      • Berenguer M.
      • Buti M.
      • et al.
      Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: an updated EASL position paper.
      J Hepatol. 2022; 77: 1161-1197
      , 
      • Kabaçam G.
      • Wahlin S.
      • Efe C.
      Autoimmune hepatitis triggered by COVID-19: a report of two cases.
      Liver Int. 2021; 41: 2527-2528
      , 
      • Codoni G.
      • Kirchner T.
      • Engel B.
      • Villamil A.M.
      • Efe C.
      • Stättermayer A.F.
      • et al.
      Histological and serological features of acute liver injury after SARS-CoV-2 vaccination.
      JHEP Rep. 2022; https://doi.org/10.1016/j.jhepr.2022.100605
      , 
      • Kulkarni A.V.
      • Vasireddy S.
      • Sharma M.
      • Reddy N.D.
      • Padaki N.R.
      COVID-19 masquerading as autoimmune hepatitis (AIH) flare-the first report.
      J Clin Exp Hepatol. 2022; 12: 241-243
      , 
      • Patel A.H.
      • Amin R.
      • Lalos A.T.
      Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination.
      Hepatol Forum. 2022; 3: 97-99https://doi.org/10.14744/hf.2022.2022.0019
      Most cases developed ALI following mRNA or viral vector-based vaccines, while only a few reports described the development of ALI after inactivated SARS-CoV-2 vaccines.
      • Efe C.
      • Kulkarni A.V.
      • Terziroli Beretta-Piccoli B.
      • Magro B.
      • Stättermayer A.
      • Cengiz M.
      • et al.
      Hepatology. 2022; (10.1002/hep.32572)https://doi.org/10.1002/hep.32572
      Recently, Wong et al.
      • Wong C.K.H.
      • Mak L.Y.
      • Au I.C.H.
      • Lai F.T.T.
      • Li X.
      • Wan E.Y.F.
      • et al.
      Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines.
      J Hepatol. 2022; https://doi.org/10.1016/j.jhep.2022.06.032
      evaluated the risk of ALI in a large cohort of vaccine recipients. They reported that the risk of ALI did not increase due to any formulation of SARS-CoV-2 vaccination. We reviewed our cohort of patients who developed ALI after inactivated SARS-CoV-2 vaccination.

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      References

        • Efe C.
        • Kulkarni A.V.
        • Terziroli Beretta-Piccoli B.
        • Magro B.
        • Stättermayer A.
        • Cengiz M.
        • et al.
        Hepatology. 2022; (10.1002/hep.32572)https://doi.org/10.1002/hep.32572
        View in Article
        • Efe C.
        • Dhanasekaran R.
        • Lammert C.
        • Ebik B.
        • Higuera-de la Tijera F.
        • Aloman C.
        • et al.
        Outcome of COVID-19 in patients with autoimmune hepatitis: an international multicenter study.
        Hepatology. 2022; 76: 1576-1586
        View in Article
        • Marjot T.
        • Eberhardt C.S.
        • Boettler T.
        • Belli L.S.
        • Berenguer M.
        • Buti M.
        • et al.
        Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: an updated EASL position paper.
        J Hepatol. 2022; 77: 1161-1197
        View in Article
        • Kabaçam G.
        • Wahlin S.
        • Efe C.
        Autoimmune hepatitis triggered by COVID-19: a report of two cases.
        Liver Int. 2021; 41: 2527-2528
        View in Article
        • Codoni G.
        • Kirchner T.
        • Engel B.
        • Villamil A.M.
        • Efe C.
        • Stättermayer A.F.
        • et al.
        Histological and serological features of acute liver injury after SARS-CoV-2 vaccination.
        JHEP Rep. 2022; https://doi.org/10.1016/j.jhepr.2022.100605
        View in Article
        • Kulkarni A.V.
        • Vasireddy S.
        • Sharma M.
        • Reddy N.D.
        • Padaki N.R.
        COVID-19 masquerading as autoimmune hepatitis (AIH) flare-the first report.
        J Clin Exp Hepatol. 2022; 12: 241-243
        View in Article
        • Patel A.H.
        • Amin R.
        • Lalos A.T.
        Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination.
        Hepatol Forum. 2022; 3: 97-99https://doi.org/10.14744/hf.2022.2022.0019
        View in Article
        • Wong C.K.H.
        • Mak L.Y.
        • Au I.C.H.
        • Lai F.T.T.
        • Li X.
        • Wan E.Y.F.
        • et al.
        Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines.
        J Hepatol. 2022; https://doi.org/10.1016/j.jhep.2022.06.032
        View in Article
        • Efe C.
        • Harputluoğlu M.
        • Soylu N.K.
        • Yilmaz S.
        Letter to the editor: liver transplantation following severe acute respiratory syndrome-coronavirus-2 vaccination-induced liver failure.
        Hepatology. 2022; 75: 1669-1671
        View in Article
        • Efe C.
        • Taşçılar K.
        • Gerussi A.
        • Bolis F.
        • Lammert C.
        • Ebik B.
        • et al.
        SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis.
        J Autoimmun. 2022; 132102906
        View in Article

      Article info

      Publication history

      Published online: November 06, 2022
      Accepted: October 25, 2022
      Received in revised form: October 24, 2022
      Received: October 5, 2022

      Footnotes

      Author names in bold designate shared first authorship.

      Identification

      DOI: https://doi.org/10.1016/j.jhep.2022.10.026

      Copyright

      © 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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