October 2012

Editorial Board
Published in issue: October 2012
iii

EASL Fellowships & Call for Schools of Hepatology
Published in issue: October 2012
iv

The International Liver Congress^™, Amsterdam 2013
Published in issue: October 2012
v

EASL Monothematic Conference co-sponsored by EACS: HIV & the liver, London 2012
Published in issue: October 2012
vi

EASL iLiver app for iPhone & iPad
Published in issue: October 2012
vii

Contents
Published in issue: October 2012
ix-xi

EASL Monothematic Conference: Systems biology of the liver, Luxembourg 2013
Published in issue: October 2012
xii

Focus

Focus
• Daniel Shouval
Published online: July 23, 2012
p713-714
Open Access

Editorials

To have B or not to have B: Vaccine and the potential eradication of hepatitis B
• Harvey J. Alter
Published online: July 04, 2012
p715-717
Open Access
The liver’s imprint on CD8⁺ T cell priming
• Percy A. Knolle
Published online: July 17, 2012
p718-719
Open Access

Research Articles

Viral Hepatitis


Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors
• Cheng-Hao Huang,
• Quan Yuan,
• Pei-Jer Chen,
• ...
• Sheng-Xiang Ge,
• Jun Zhang,
• Ning-Shao Xia
Published online: May 25, 2012
p720-729

Minimization of hepatitis B infection by a 25-year universal vaccination program
• Yen-Hsuan Ni,
• Mei-Hwei Chang,
• Jia-Feng Wu,
• Hong-Yuan Hsu,
• Huey-Ling Chen,
• Ding-Shinn Chen
Published online: June 04, 2012
p730-735

A population-based study of the epidemiology of hepatitis C in a North American population
• Julia Uhanova,
• Robert B Tate,
• Douglas J Tataryn,
• Gerald Y Minuk
Published online: June 04, 2012
p736-742

All-cause and liver-related mortality in HIV positive subjects compared to the general population: Differences by HCV co-infection
• Victoria Hernando,
• Santiago Perez-Cachafeiro,
• Charlotte Lewden,
• ...
• Santiago Moreno,
• Julia del Amo
• CoRIS
Published online: June 18, 2012
p743-751

Cirrhosis


The role of CX₃CL1/CX₃CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome
• Junlan Zhang,
• Wenli Yang,
• Bao Luo,
• Bingqian Hu,
• Akhil Maheshwari,
• Michael B. Fallon
Published online: May 30, 2012
p752-758

Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study
• Mónica Guevara,
• Carlos Terra,
• André Nazar,
• ...
• Marco Pavesi,
• Vicente Arroyo,
• Pere Ginès
Published online: June 25, 2012
p759-765

Liver Failure and Growth


Nilotinib protects the murine liver from ischemia/reperfusion injury
• Lee M. Ocuin,
• Shan Zeng,
• Michael J. Cavnar,
• ...
• Teresa S. Kim,
• Rachel Popow,
• Ronald P. DeMatteo
Published online: May 28, 2012
p766-773

The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure
• Peter Nissen Bjerring,
• John Hauerberg,
• Hans-Jørgen Frederiksen,
• Henning Bay Nielsen,
• Jens Otto Clemmesen,
• Fin Stolze Larsen
Published online: June 11, 2012
p774-779

Evaluation of coagulation abnormalities in acute liver failure
• Banwari Agarwal,
• Gavin Wright,
• Alex Gatt,
• ...
• Andrew Davenport,
• Rajiv Jalan,
• Andrew Burroughs
Published online: June 25, 2012
p780-786

Cancer


Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct
• Geunyoung Jung,
• Kwang-Min Park,
• Seung Soo Lee,
• Eunsil Yu,
• Seung-Mo Hong,
• Jihun Kim
Published online: May 24, 2012
p787-793

A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma
• Kai Feng,
• Jun Yan,
• Xiaowu Li,
• ...
• Shuguang Wang,
• Ping Bie,
• Jiahong Dong
Published online: May 24, 2012
p794-802

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats
• Hui-Lu Zhang,
• Le-Xing Yu,
• Wen Yang,
• ...
• Zhong Li,
• He-Xin Yan,
• Hong-Yang Wang
Published online: June 20, 2012
p803-812

Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
• Alessandra Gentilini,
• Krista Rombouts,
• Sara Galastri,
• ...
• Massimo Roncalli,
• Pietro Invernizzi,
• Massimo Pinzani
Published online: June 21, 2012
p813-820

Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial
• Jordi Bruix,
• Jean-Luc Raoul,
• Morris Sherman,
• ...
• Marius Moscovici,
• Dimitris Voliotis,
• Josep M. Llovet
Published online: June 20, 2012
p821-829
Open Access

Molecular and Cell Biology


Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a “neglected” IL-2^low Bim^high phenotype, poor CTL function and cell death
• Lauren E. Holz,
• Volker Benseler,
• Michelle Vo,
• ...
• Geoffrey W. McCaughan,
• David G. Bowen,
• Patrick Bertolino
Published online: June 04, 2012
p830-836

Genetic and Metabolic Diseases


p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice
• Kengo Tomita,
• Toshiaki Teratani,
• Takahiro Suzuki,
• ...
• Takanori Kanai,
• Soichiro Miura,
• Toshifumi Hibi
Published online: May 28, 2012
p837-843

A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes
• Keisuke Kakisaka,
• Sophie C. Cazanave,
• Nathan W. Werneburg,
• ...
• Joachim C. Mertens,
• Steve F. Bronk,
• Gregory J. Gores
Published online: May 28, 2012
p844-851

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
• Claudia von Montfort,
• Núria Matias,
• Anna Fernandez,
• ...
• Neil Kaplowitz,
• Carmen Garcia-Ruiz,
• Jose C. Fernandez-Checa
Published online: June 11, 2012
p852-859

Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
• Mohamed A. Abdelmegeed,
• Atrayee Banerjee,
• Seong-Ho Yoo,
• Sehwan Jang,
• Frank J. Gonzalez,
• Byoung-Joon Song
Published online: June 04, 2012
p860-866

The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance
• Amir Shlomai,
• Maya Mouler Rechtman,
• Ela Olga Burdelova,
• ...
• Sigal Fishman,
• Zamir Halpern,
• Ella H. Sklan
Published online: June 25, 2012
p867-873

Reviews

Assessment of risk for non-hepatic surgery in cirrhotic patients
• Prashant Bhangui,
• Alexis Laurent,
• Roland Amathieu,
• Daniel Azoulay
Published online: May 23, 2012
p874-884
Open Access

Chronic hepatitis B in children and adolescents
• Massimiliano Paganelli,
• Xavier Stephenne,
• Etienne M. Sokal
Published online: May 24, 2012
p885-896
Open Access

D-livering the message: The importance of vitamin D status in chronic liver disease
• Matthew T. Kitson,
• Stuart K. Roberts
Published online: May 24, 2012
p897-909
Open Access

Special Sections

International Hepatology


How transient becomes stable: An epigenetic switch linking liver inflammation and tumorigenesis
• Stefano Cairo,
• Marie Annick Buendia
Published online: June 04, 2012
p910-912
Open Access

Hepatology Snapshot


New directions for cell-based therapies in acute liver failure
• Preeti Viswanathan,
• Sanjeev Gupta
Published online: June 18, 2012
p913-915
Open Access

Clinical Application of Basic Science


Pathological roles of purinergic signaling in the liver
• Byron P. Vaughn,
• Simon C. Robson,
• Geoffrey Burnstock
Published online: June 18, 2012
p916-920

Letters to the Editor

Neuroinflammation in HCV-infection – Peril or protection?
• Henning Pflugrad,
• Xiaoqi Q. Ding,
• Hans L. Tillmann,
• Karin Weissenborn
Published online: June 15, 2012
p921-922
Open Access
Reply to: “Neuroinflammation in HCV-infection – Peril or protection?”
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition
• Valerie Byrnes,
• Damien Lowry,
• David Alsop,
• Nezam H. Afdhal
Published online: June 14, 2012
p923-924
Open Access
Why 88% of US military veterans with HCV are not treated
• Bennet Cecil
Published online: April 16, 2012
p924
Open Access
Noradrenaline in the treatment of patients with hepatorenal syndrome – Back to the roots?
• Kurt Lenz
Published online: June 21, 2012
p925
Open Access
Reply to: “Noradrenaline in the treatment of patients with hepatorenal syndrome – Back to the roots?”
• Virendra Singh,
• Souvik Ghosh,
• Narendra S. Choudhary
Published online: June 14, 2012
p926
Open Access
Week 4 viral response to peginterferon and ribavirin: How should it be used in combination with a baseline predictive factor?
• Hidenori Toyoda,
• Takashi Kumada,
• Yoshiaki Katano,
• Hidemi Goto
Published online: June 14, 2012
p927-928
Open Access
Encephalopathy or hepatic encephalopathy?
• Sara Montagnese,
• Carlo Merkel,
• Piero Amodio
Published online: June 15, 2012
p928-929
Open Access
Reply to: “Encephalopathy or hepatic encephalopathy?”
Management of critically-ill cirrhotic patients
• François Durand,
• Pere Ginès,
• Faouzi Saliba,
• Javier Fernández
Published online: June 18, 2012
p929-930
Open Access
Contrast enhanced ultrasound for the diagnosis of hepatocellular carcinoma (HCC): Comments on AASLD guidelines
• Ana Paula Barreiros,
• Fabio Piscaglia,
• Christoph F. Dietrich
Published online: June 14, 2012
p930-932
Open Access
Regulatory T cells in autoimmune hepatitis
• Maria Serena Longhi,
• Yun Ma,
• Giorgina Mieli-Vergani,
• Diego Vergani
Published online: June 18, 2012
p932-933
Open Access
Reply to: “Regulatory T cells in autoimmune hepatitis”
• Moritz Peiseler,
• Marcial Sebode,
• Christoph Schramm,
• Johannes Herkel
Published online: June 18, 2012
p933-934
Open Access

EASL Basic School of Hepatology Course 8: Stem cells and the liver, Edinburgh, 2013
Published in issue: October 2012
I

EASL iLiver app for iPhone & iPad
Published in issue: October 2012
II