October 2020

Editorial Board
Published in issue: October 2020
i

The International Liver Congress™ 2021
Published in issue: October 2020
ii

The Digital Liver Cancer Summit 2021
Published in issue: October 2020
iii

Discover the EASL Campus: your open-access eLearning Hub
Published in issue: October 2020
iv

Join the EASL Community
Published in issue: October 2020
v

Contents
Published in issue: October 2020
vii-ix

From the Editor's Desk

From the Editor's Desk...
• Patrizia Burra,
• Frank Tacke,
• Vlad Ratziu,
• Stefan Zeuzem,
• Bruno Sangro,
• Paolo Angeli
Published in issue: October 2020
p745-748

JHEP at a Glance

JHEP at a glance (October 2020)
Published in issue: October 2020
e49-e63

Editorials

From mice to humans: Unravelling the genetic levers of NASH
• Wajahat Zafar Mehal
Published online: August 14, 2020
p749-751
About the absolute need to keep active research on the efficacy of direct-acting antiviral drugs against the hepatitis C virus
• Jean-Michel Pawlotsky
Published online: July 27, 2020
p752-754
Acute-on-chronic liver failure: The challenge of PREDICTing who and when
• Alistair O'Brien,
• Constantine J. Karvellas
Published online: August 13, 2020
p755-756

Research Articles

NAFLD and Alcohol-Related Liver Diseases


Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages^☆
• Sander Lefere,
• Tobias Puengel,
• Jana Hundertmark,
• ...
• Lindsey Devisscher,
• Guillaume Wettstein,
• Frank Tacke
Published online: April 29, 2020
p757-770

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation
• Kristin Schwerbel,
• Anne Kamitz,
• Natalie Krahmer,
• ...
• Heike Vogel,
• Wenke Jonas,
• Annette Schürmann
Published online: May 03, 2020
p771-782
Open Access

ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development
• Qing Song,
• Yingli Chen,
• Jun Wang,
• ...
• Zhaoli Sun,
• Zhangxiang Zhou,
• Zhenyuan Song
Published online: May 07, 2020
p783-793

Viral Hepatitis


Efficacy of NS5A inhibitors against unusual and potentially difficult-to-treat HCV subtypes commonly found in sub-Saharan Africa and South East Asia
• Dung Nguyen,
• David Smith,
• Alun Vaughan-Jackson,
• ...
• STOP-HCV Consortium,
• Eleanor Barnes,
• Peter Simmonds
Published online: May 26, 2020
p794-799

Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B
• Lung-Yi Mak,
• Rex Wan-Hin Hui,
• James Fung,
• ...
• Ka-Shing Cheung,
• Man-Fung Yuen,
• Wai-Kay Seto
Published online: June 02, 2020
p800-806

SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19
• Yijin Wang,
• Shuhong Liu,
• Hongyang Liu,
• ...
• Shousong Zhao,
• Jiangyang Lu,
• Jingmin Zhao
Published online: May 10, 2020
p807-816

Cirrhosis and Liver Failure


Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis^☆
• Cristina López-Vicario,
• Antonio Checa,
• Arantxa Urdangarin,
• ...
• Vicente Arroyo,
• Craig E. Wheelock,
• Joan Clària
Published online: April 12, 2020
p817-828

Short-term hemodynamic effects of β-blockers influence survival of patients with decompensated cirrhosis
• Edilmar Alvarado-Tapias,
• Alba Ardevol,
• Marta Garcia-Guix,
• ...
• Carles Aracil,
• Ferran Torres,
• Càndid Villanueva
Published online: April 13, 2020
p829-841

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
• Jonel Trebicka,
• Javier Fernandez,
• Maria Papp,
• ...
• Paolo Angeli,
• Vicente Arroyo
• for the PREDICT STUDY group of the EASL-CLIF Consortium
Published online: July 13, 2020
p842-854
Open Access

Hepatic and Biliary Cancer


A nomogram based on liver stiffness predicts postoperative complications in patients with hepatocellular carcinoma
• Matteo Serenari,
• Kwang-Hyub Han,
• Federico Ravaioli,
• ...
• Davide Festi,
• Antonio Daniele Pinna,
• Matteo Cescon
Published online: April 30, 2020
p855-862

Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project
• Sarah S. Jackson,
• Hans-Olov Adami,
• Gabriella Andreotti,
• ...
• Katherine A. McGlynn,
• Peter T. Campbell,
• Jill Koshiol
Published online: May 10, 2020
p863-872

Liver Transplantation


An international multicenter study of protocols for liver transplantation during a pandemic: A case for quadripartite equipoise
• Claire Alexandra Chew,
• Shridhar Ganpathi Iyer,
• Alfred Wei Chieh Kow,
• ...
• Paolo Muiesan,
• Darius F. Mirza,
• Glenn Kunnath Bonney
Published online: May 22, 2020
p873-881

Experimental and Translational Hepatology


TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis
• Yoshinori Okina,
• Misako Sato-Matsubara,
• Tsutomu Matsubara,
• ...
• Katsutoshi Yoshizato,
• Massimo Pinzani,
• Norifumi Kawada
Published online: April 20, 2020
p882-895
Open Access

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation
• Jamie Bates,
• Archana Vijayakumar,
• Sarani Ghoshal,
• ...
• Li Li,
• Bryan C. Fuchs,
• David G. Breckenridge
Published online: May 03, 2020
p896-905
Open Access

Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma
• Zhi-Peng Peng,
• Ze-Zhou Jiang,
• Hao-Fan Guo,
• ...
• Jin-Hua Huang,
• Limin Zheng,
• Yan Wu
Published online: May 12, 2020
p906-917

Reviews

Tissue engineering of the biliary tract and modelling of cholestatic disorders
• Teresa Brevini,
• Olivia C. Tysoe,
• Fotios Sampaziotis
Published online: June 11, 2020
p918-932

Danger signals in liver injury and restoration of homeostasis
• Hui Han,
• Romain Desert,
• Sukanta Das,
• ...
• Dipti Athavale,
• Xiaodong Ge,
• Natalia Nieto
Published online: May 03, 2020
p933-951

Occult hepatitis B infection and hepatocellular carcinoma: Epidemiology, virology, hepatocarcinogenesis and clinical significance
• Lung-Yi Mak,
• Danny Ka-Ho Wong,
• Teresa Pollicino,
• Giovanni Raimondo,
• F. Blaine Hollinger,
• Man-Fung Yuen
Published online: June 02, 2020
p952-964

Special Section

Hepatology Snapshot


Primary biliary cholangitis: a multifaceted pathogenesis with potential therapeutic targets
• Marco Carbone,
• Chiara Milani,
• Alessio Gerussi,
• Vincenzo Ronca,
• Laura Cristoferi,
• Pietro Invernizzi
Published online: July 21, 2020
p965-966

Letters to the Editor

Hepatocellular type II fibrinogen inclusions in a patient with severe COVID-19 and hepatitis
• Montserrat Fraga,
• Darius Moradpour,
• Florent Artru,
• ...
• Alessandro Casini,
• Lorenzo Alberio,
• Christine Sempoux
Published online: June 22, 2020
p967-970

Extending the mode of action of triethylenetetramine (trientine): Autophagy besides copper chelation
• Federico Pietrocola,
• Francesca Castoldi,
• Hans Zischka,
• Guido Kroemer
Published online: July 16, 2020
p970-972
Stereotactic body radiation therapy vs. radiofrequency ablation for HCC: More questions than answers
• Teh-Ia Huo,
• Shu-Yein Ho,
• Chih-Chieh Ko
Published online: August 05, 2020
p972-973
Reply to: “Stereotactic body radiation therapy vs. radiofrequency ablation for HCC: More questions than answers”
• Nalee Kim,
• Jinsil Seong
Published online: July 06, 2020
p973-974

Extracorporeal portosystemic shunt in secondary Budd-Chiari syndrome
• Bernhard C. Meyer,
• Jan B. Hinrichs,
• Philipp Ivanyi,
• ...
• Mark Greer,
• Marius M. Hoeper,
• Markus Busch
Published online: July 16, 2020
p974-976
Pre-emptive TIPS for acute variceal bleeding in acute-on-chronic liver failure: Is there enough evidence for a routine recommendation?
• Anshuman Elhence,
• Ramesh Kumar,
• Shalimar
Published online: July 11, 2020
p976-977

Reply to: “Pre-emptive TIPS for acute variceal bleeding in acute-on-chronic liver failure: Is there enough evidence for a routine recommendation?”
pTIPS for variceal bleeding in ACLF patients: when and why?
• Jonel Trebicka,
• Wenyi Gu,
• Juan Carlos Garcia-Pagán,
• Jaime Bosch,
• Rafael Bañares
Published online: July 17, 2020
p977-979

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?
• Katharina Maria Schwarzkopf,
• Larissa Eberle,
• Frank Erhard Uschner,
• ...
• Christian Markus Lange,
• Jonel Trebicka,
• Christoph Welsch
Published online: July 19, 2020
p980-982
Open Access

Reply to: “Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?”
The search for an optimal mouse model
• Xiaogang Xiang,
• Seonghwan Hwang,
• Bin Gao
Published online: July 17, 2020
p982-984
HCV treatment in cirrhotic patients: Should we use a different approach for patients awaiting a liver transplant
• Lucy Meunier,
• Georges-Philippe Pageaux,
• Audrey Coilly
Published online: July 08, 2020
p984-985
Reply to: “HCV treatment in cirrhotic patients: Should we use a different approach for patients awaiting a liver transplant”
• Elizabeth C. Verna,
• Lucy Akushevich,
• Monika Vainorius,
• Michael W. Fried,
• K. Rajender Reddy
• On behalf of HCV TARGET
Published online: July 15, 2020
p985-986
Liver stiffness: A novel predictor of postoperative complications in patients with hepatocellular carcinoma
• Gang Xu,
• Yao Xiao,
• Bao Jin,
• Xinting Sang,
• Shunda Du,
• Yilei Mao
Published online: July 20, 2020
p987
Reply to: “Liver stiffness: A novel predictor of postoperative complications in patients with hepatocellular carcinoma”
• Matteo Serenari,
• Federico Ravaioli,
• Alessandro Cucchetti,
• Seung-Up Kim,
• Matteo Cescon
Published online: July 20, 2020
p988-989
Characteristics of pregnant patients with COVID-19 and liver injury
• Guangtong Deng,
• Furong Zeng,
• Lijuan Zhang,
• Hui Chen,
• Xiang Chen,
• Mingzhu Yin
Published online: June 19, 2020
p989-991
SARS-CoV-2 related liver impairment – perception may not be the reality
• Cyriac Abby Philips,
• Rizwan Ahamed,
• Philip Augustine
Published online: May 23, 2020
p991-992

Single cell RNA sequencing analysis did not predict hepatocyte infection by SARS-CoV-2
• Vincent De Smet,
• Stefaan Verhulst,
• Leo A. van Grunsven
Published online: May 27, 2020
p993-995
SARS-CoV-2: Is the liver merely a bystander to severe disease?
• Mansoor N. Bangash,
• Jaimin M. Patel,
• Dhruv Parekh,
• ...
• Gautam Mehta,
• Matthew J. Armstrong,
• Desley Neil
Published online: June 02, 2020
p995-996
Reply to: Correspondence relating to “SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19”
• Yijin Wang,
• Fengmin Lu,
• Jingmin Zhao
Published online: June 23, 2020
p996-998

Erratum

Erratum to: ‘Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance’ (J Hepatol 2019; 71(1): 14-24)
• Sabrina J. Merat,
• Camille Bru,
• Dorien van de Berg,
• ...
• Hergen Spits,
• Tim Beaumont,
• Janke Schinkel
Published online: August 01, 2020
p999-1000