February 2021

Editorial Board
Published in issue: February 2021
i

Learn more about the International Liver Congress™ 2021
Published in issue: February 2021
ii

Register now for the Digital Liver Cancer Summit 2021
Published in issue: February 2021
iii

Discover the EASL Schools 2021
Published in issue: February 2021
iv

Sign up to EASL Campus: your open-access eLearning Hub
Published in issue: February 2021
v

Contents
Published in issue: February 2021
vii-ix

From the Editor's Desk

From the Editor's Desk…
• Patrizia Burra,
• Frank Tacke,
• Vlad Ratziu,
• Stefan Zeuzem,
• Bruno Sangro,
• Paolo Angeli
Published in issue: February 2021
p265-268

JHEP at a Glance

JHEP at a glance (February 2021)
Published in issue: February 2021
e17-e31

Editorials

Hyperprogression in hepatocellular carcinoma: Illusion or reality?
• Stephen L. Chan
Published online: October 24, 2020
p269-271
Contrast-enhanced ultrasound of the liver in colorectal cancer: A useful tool in the right patient
• Fabio Piscaglia,
• Vito Sansone,
• Francesco Tovoli
Published online: December 10, 2020
p272-273

Research Articles

NAFLD and Alcohol-Related Liver Diseases


Emricasan to prevent new decompensation in patients with NASH-related decompensated cirrhosis
• Catherine Frenette,
• Zeid Kayali,
• Edward Mena,
• ...
• David T. Hagerty,
• Kris V. Kowdley
• for the IDN-6556-17 Study Investigators
Published online: October 07, 2020
p274-282

Viral Hepatitis


Composition of HBsAg is predictive of HBsAg loss during treatment in patients with HBeAg-positive chronic hepatitis B
• Maria Pfefferkorn,
• Tina Schott,
• Stephan Böhm,
• ...
• Renate Heyne,
• Thomas Berg,
• Florian van Bömmel
Published online: September 12, 2020
p283-292

High hepatitis C treatment uptake among people with recent drug dependence in New South Wales, Australia
• Heather Valerio,
• Maryam Alavi,
• Matthew Law,
• ...
• Louisa Degenhardt,
• Jason Grebely,
• Gregory J. Dore
Published online: September 12, 2020
p293-302

Reduced incidence of hepatitis C in 9 villages in rural Egypt: Progress towards national elimination goals
• Gamal Shiha,
• Reham Soliman,
• Nabiel N.H. Mikhail,
• Philippa Easterbrook
Published online: September 12, 2020
p303-311

DILI, Autoimmune, Cholestatic and Genetic Diseases


Update of the simplified criteria for autoimmune hepatitis: Evaluation of the methodology for immunoserological testing
• Johanna Galaski,
• Christina Weiler-Normann,
• Miriam Schakat,
• ...
• Marco Lenzi,
• George N. Dalekos,
• Ansgar W. Lohse
Published online: July 27, 2020
p312-320

A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA
• Gideon M. Hirschfield,
• Ulrich Beuers,
• Limas Kupcinskas,
• ...
• Dominique Wendum,
• Uta Drebber,
• Raoul Poupon
Published online: September 16, 2020
p321-329
Open Access

Cirrhosis and Liver Failure


Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure^☆
• Florence Wong,
• Salvatore Piano,
• Virendra Singh,
• ...
• Adrian Gadano,
• Paolo Angeli
• on behalf of the International Club of Ascites Global Study Group
Published online: August 08, 2020
p330-339

On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites^☆
• Paolo Caraceni,
• Manuel Tufoni,
• Giacomo Zaccherini,
• ...
• Maurizio Baldassarre,
• Mauro Bernardi
• for the ANSWER Study Investigators
Published online: August 24, 2020
p340-349

Hepatic and Biliary Cancer


Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma
• Chang Gon Kim,
• Chan Kim,
• Sang Eun Yoon,
• ...
• Hong Jae Chon,
• Hye Jin Choi,
• Ho Yeong Lim
Published online: August 15, 2020
p350-359

RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma
• Lo-Kong Chan,
• Daniel Wai-Hung Ho,
• Charles Shing Kam,
• ...
• Tan-To Cheung,
• Chun-Ming Wong,
• Irene Oi-Lin Ng
Published online: September 09, 2020
p360-371

Liver Transplantation


Simultaneous splenectomy improves outcomes after adult living donor liver transplantation
• Tomoharu Yoshizumi,
• Shinji Itoh,
• Mototsugu Shimokawa,
• ...
• Toru Ikegami,
• Yuji Soejima,
• Masaki Mori
Published online: August 19, 2020
p372-379

Experimental and Translational Hepatology


Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
• Manuel Winkler,
• Theresa Staniczek,
• Sina Wietje Kürschner,
• ...
• Cyrill Géraud,
• Philipp-Sebastian Koch,
• Sergij Goerdt
Published online: September 08, 2020
p380-393
Open Access

Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
• Pui Y. Lee-Law,
• Paula Olaizola,
• Francisco J. Caballero-Camino,
• ...
• Luis Bujanda,
• Joost P.H. Drenth,
• Jesus M. Banales
Published online: September 17, 2020
p394-406
Open Access

Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice
• Neele Schumacher,
• Karsten Yan,
• Monja Gandraß,
• ...
• Hans-Willi Mittrücker,
• Stefan Rose-John,
• Dirk Schmidt-Arras
Published online: September 24, 2020
p407-418

Innovative Diagnostics, Modelling and Digital Hepatology


Contrast-enhanced ultrasound can guide the therapeutic strategy by improving the detection of colorectal liver metastases
• Mikael Sawatzki,
• Ulrich Güller,
• Sabine Güsewell,
• Daniela B. Husarik,
• David Semela,
• Stephan Brand
Published online: October 13, 2020
p419-427

Reviews

Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia
• David C. Trampert,
• Stan F.J. van de Graaf,
• Aldo Jongejan,
• Ronald P.J. Oude Elferink,
• Ulrich Beuers
Published online: October 23, 2020
p428-441
Open Access

Hepatokines and adipokines in NASH-related hepatocellular carcinoma
• Ozlem Kucukoglu,
• Jan-Peter Sowa,
• Guillermo Daniel Mazzolini,
• Wing-Kin Syn,
• Ali Canbay
Published online: November 05, 2020
p442-457
Open Access

Special Sections

Thematic Miniseries on HCV cure


HCC surveillance after SVR in patients with F3/F4 fibrosis
• George N. Ioannou
Published online: December 07, 2020
p458-465

Hepatology Snapshot


Liver zonation
• Rita Manco,
• Shalev Itzkovitz
Published online: December 11, 2020
p466-468

Letters to the Editor

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points
• Marcos F. Fondevila,
• Maria Mercado-Gómez,
• Amaia Rodríguez,
• ...
• Gema Frühbeck,
• Maria L. Martinez-Chantar,
• Ruben Nogueiras
Published online: October 19, 2020
p469-471

Tobacco, cannabis, and liquorice: Hidden players altering albendazole metabolism in patients with hepatic alveolar echinococcosis
• Solange Bresson-Hadni,
• Damien Montange,
• Carine Richou,
• ...
• Frédéric Grenouillet,
• Dominique-Angèle Vuitton,
• Laurence Millon
Published online: December 10, 2020
p471-473
EASL recommendations on treatment of hepatitis C: Final update of the series – Some issues
• Chia-Yen Dai,
• Wan-Long Chuang,
• Ming-Lung Yu
Published online: November 19, 2020
p473-474
Reply to: “EASL recommendations on treatment of hepatitis C: Final update of the series – some issues”
• EASL Recommendations on Treatment of Hepatitis C Panel
Published online: November 20, 2020
p474-475
The role of the model for end-stage liver disease-sodium score and joint models for 90-day mortality prediction in patients with acute-on-chronic liver failure
• Ben F.J. Goudsmit,
• Maarten E. Tushuizen,
• Hein Putter,
• Andries E. Braat,
• Bart van Hoek
Published online: November 17, 2020
p475-476
Reply to: “The role of the model for end-stage liver disease sodium score and joint models for 90-day mortality prediction in in patients with acute-on-chronic liver failure”
• Ruben Hernaez,
• Fasiha Kanwal
Published online: November 23, 2020
p477
PREDICTing acute-on-chronic liver failure in patients with acute decompensation
• Abhinav Anand,
• Ramesh Kumar,
• Shalimar
Published online: December 03, 2020
p478-479
Pre-acute-on-chronic liver failure in hepatitis B-related patients
• Xiaoting Tang,
• Tingting Qi,
• Beiling Li,
• Jinjun Chen
Published online: December 02, 2020
p479-480
Reply to: Correspondence on ‘The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology’
• Jonel Trebicka,
• Javier Fernandez,
• Vicente Arroyo
• for the PREDICT STUDY group of the EASL-CLIF CONSORTIUM
Published online: December 02, 2020
p480-481
NAFLD is a predictor of liver injury in COVID-19 hospitalized patients but not of mortality, disease severity on the presentation or progression – The debate continues
• Kamran Mushtaq,
• Muhammad Umair Khan,
• Fatima Iqbal,
• ...
• Khalid Al-Ejji,
• Saad AlKaabi,
• Yasser Medhat Kamel
Published online: November 19, 2020
p482-484
Reply to: “NAFLD is a predictor of liver injury in COVID-19 hospitalized patients but not of mortality, disease severity on the presentation or progression – The debate continues”
• Dong Ji,
• Gregory Cheng,
• George Lau
Published online: October 29, 2020
p484-485
Open or closed window: That is the question
• Cristina Ripoll,
• Alexander Zipprich
Published online: December 08, 2020
p485-486
Reply to: “Open or closed window: That is the question”
• Luis Téllez,
• Rafael Bañares,
• Agustín Albillos
Published online: December 10, 2020
p486-487
Is the increased risk for MAFLD patients to develop severe COVID-19 linked to perturbation of the gut-liver axis?
• Gabriella Assante,
• Roger Williams,
• Neil Alexander Youngson
Published online: June 20, 2020
p487-488
Relevance of platelet-derived microvesicles in cirrhosis: The debate remains open
• Delphine Weil,
• Thierry Thévenot,
• Philippe Saas,
• Vincent Di Martino
Published online: December 02, 2020
p488-490

Corrigendum

Corrigendum to “Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules” [J Hepatol (2019) 874–884]
• Zoe Mariño,
• Anna Darnell,
• Sabela Lens,
• ...
• Xavier Forns,
• Jordi Bruix,
• María Reig
Published online: December 11, 2020
p491